The effect of cyclooxygenase-2 on dopaminergic neurons in substantia nigra of Parkinson's disease mice induced by MPTP / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 333-336, 2002.
Article
en Zh
| WPRIM
| ID: wpr-339725
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WPRO
ABSTRACT
<p><b>AIM AND METHODS</b>Using Strain C57/BL of COX-2 deficient mice, the effect of Cyclooxygenase-2 (COX-2) on dopaminergic neurons in substantia nigra of Parkinson's disease (PD) mice induced by intraperitoneal injections of MPTP-HCl were investigated by immunocytochemistry(ICC) .</p><p><b>RESULTS</b>We found that the mortality in COX-2 heterozygous mice is much lower than that in wild type mice (P < 0.01) after injection of MPTP (30 mg/kg/day). The result of semiquantitative immunocytochemical staining showed that the number of tyrosine hydroxylase (TH) immunoreactive neurons in the substantia nigra pars compacta (SNc) declined more significantly in MPTP-treated wild type mice than that in COX-2 heterozygotes mice (P < 0.01).</p><p><b>CONCLUSION</b>COX-2 may be related with lesion of dopaminergic neurons in the SNc of PD.</p>
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Índice:
WPRIM
Asunto principal:
Enfermedad de Parkinson
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Patología
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Sustancia Negra
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Ciclooxigenasa 2
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Ratones Endogámicos C57BL
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Neuronas
Límite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Año:
2002
Tipo del documento:
Article