Effects of estrogen on collagen gel contraction by human retinal glial cells / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 4098-4103, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-339893
ABSTRACT
<p><b>BACKGROUND</b>There are definite gender differences in patients with macular holes. Menopausal women over 50 years are most affected. We aimed to observe the effect of estrogen on collagen gel contraction by cultured human retinal glial cells. It is speculated that estrogen could strengthen the tensile stress of the macula by maintaining the correct morphology and contraction.</p><p><b>METHODS</b>Estrogen was used to determine its effects on collagen gel contraction, and its function was measured using morphological changes in cells. Human retinal glial cells were cultured in collagen solution. The cells were then exposed to collagen gels and the degree of contraction of the gel was determined.</p><p><b>RESULTS</b>Estrogen at differing concentrations had no effect on the growth of human retinal glial cells. However, after exposed to collagen gel block, less contraction was noted in the estrogen-treated group than in the control group.</p><p><b>CONCLUSIONS</b>Estrogen can inhibit collagen gel contraction by glial cells. These results suggest a mechanism for macular hole formation, which is observed in menopausal females.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Ensayo de Inmunoadsorción Enzimática
/
Células Cultivadas
/
Neuroglía
/
Colágeno
/
Estrógenos
/
Metabolismo
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Chinese Medical Journal
Año:
2012
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS