Effects of extremely low frequency electromagnetic fields on apoptosis and cell cycle of mouse brain and liver cells / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
; (12): 339-341, 2003.
Article
en Zh
| WPRIM
| ID: wpr-340043
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of extremely low frequency electromagnetic fields (ELF EMFs) on apoptosis and cell cycle of mouse brain and liver cells.</p><p><b>METHODS</b>Mice were exposed to 50 Hz, 0.2 mT or 6.0 mT electromagnetic fields for 2 weeks. TUNEL and flow cytometric methods were used to analyze apoptosis and cell cycle of brain and liver cells.</p><p><b>RESULTS</b>After exposure to 0.2 mT and 6.0 mT ELF EMFs for 2 weeks, apoptosis rates of brain cells [(5.60 +/- 1.47)% and (4.73 +/- 0.48)% respectively] were higher than that of control [(2.90 +/- 0.75)%], and apoptosis rates of liver cells [(4.19 +/- 2.08)% and (3.38 +/- 0.65)% respectively] were higher than that of control [(1.84 +/- 0.76)%]. G0/G1 cell percentage of brain cells [(80.21 +/- 1.68)% and (79.54 +/- 0.56)% respectively] were higher than that of control [(76.85 +/- 0.83)%], and those of liver cells [(79.42 +/- 1.80)% and (80.47 +/- 1.79)% respectively] were higher than that of control [(73.36 +/- 3.10)%]. The above differences were all statistically significant as P < 0.05. At the same time S and G2 + M cell percentage of brain and liver cells were significantly decreased.</p><p><b>CONCLUSION</b>Exposure to 50 Hz EMFs may alter cell cycle and induce apoptosis of mouse brain and liver cells.</p>
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Índice:
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Asunto principal:
Efectos de la Radiación
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Encéfalo
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Ciclo Celular
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Apoptosis
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Etiquetado Corte-Fin in Situ
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Biología Celular
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Campos Electromagnéticos
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Citometría de Flujo
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Hígado
Límite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Año:
2003
Tipo del documento:
Article