Protective effects and pathogenesis of complex salvin miltiorrhiza on acute mercury poisoning in rabbits / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 341-344, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-340154
ABSTRACT
<p><b>OBJECTIVE</b>To study protective effect and pathogenesis of complex salvia miltiorrhiza (DanShen) on acute mercury poisoning in rabbits.</p><p><b>METHODS</b>Models of acute mercury poisoning was made in rabbits. The effect of complex salvia miltiorrhiza on blood urea nitrogen (BUN), copper-protein (CP), lactate dehydrogenase (LDH), acid phosphatase (ACP) and the malondialdehyde (MDA) in plasma, superoxide dismutase (SOD) in erythrocyte and MDA, SOD in tissues homogenate were observed.</p><p><b>RESULTS</b>The administration of complex salvia miltiorrhiza after mercury injection 0.5 h and 9.5 h, decreased BUN, CP, MDA, LDH and ACP, and prevented the reduction of SOD. Compared with mercury poisoning group, the difference was statistical significant (P < 0.05, P < 0.01).</p><p><b>CONCLUSION</b>It is suggested that acute mercury poisoning may result in renal damage but also multiple organ tissues, and complex salvia miltiorrhiza possesses protective effect, through stabilized membranes.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fenantrolinas
/
Sangre
/
Medicamentos Herbarios Chinos
/
Salvia miltiorrhiza
/
Usos Terapéuticos
/
Quimioterapia
/
Intoxicación por Mercurio
Tipo de estudio:
Estudio de etiología
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Applied Physiology
Año:
2010
Tipo del documento:
Artículo
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