Effect of endogenous H2S on platelet L-Arg transport / 中国应用生理学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the effect of novel air neuromodulator H2S on platelet function of L-Arg transport for discussing H2S of effect on platelet function.</p><p><b>METHODS</b>Saturate H2S solution as donate made rat rich platelet plasma and pre-incubation rat platelet with different density of H2S. To measure the velocity of L-Arg transport in platelet by radioactivity technique.</p><p><b>RESULTS</b>At different concentrations of H2S (6.25, 12.5, 25, 50, 100 micromol/L), the velocity of L-Arg transport was lower than that in control. H2S reduced rapidly the Vmax and velocity of L-Arg transport in platelet (P < 0.05) and this effect had no effect to Km.</p><p><b>CONCLUSION</b>H2S can affect platelet function by changing rapidly platelet L-Arg transport system function.</p>