Expression of MMP1 mRNA in oral squamous cell carcinoma and paired normal tissues / 南方医科大学学报
Journal of Southern Medical University
; (12): 1362-1364, 2008.
Article
en Zh
| WPRIM
| ID: wpr-340820
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the mRNA expression of matrix metalloproteinase 1 (MMP1) gene in oral squamous cell carcinoma (OSCC) and the paired normal tissues.</p><p><b>METHODS</b>The differential expression of MMP1 mRNA between 30 OSCC and paired normal tissues were detected with reverse transcription-PCR (RT-PCR).</p><p><b>RESULTS</b>The relative expression level of MMP1 mRNA in the OSCC tissues showed a 3.26-fold increase in comparison with that in the paired normal tissues (4.06-/+0.52 vs 1.24-/+0.17, P<0.0001). In the 30 OSCC tissues, the relative expression level of MMP1 mRNA was higher in histological grade II/III tissues (4.31-/+0.68) than in grade I (3.87-/+0.57) tissues, higher in OSCC in advanced stages (III/IV) than in tumors in early stages (I/II) (4.18-/+0.67 vs 3.65-/+0.53), and also higher in OSCC with cervical lymph node invasion than in those without cervical lymph node invasion (4.32-/+0.71 vs 3.91-/+0.51), but these differences were not statistically significant (P>0.05).</p><p><b>CONCLUSION</b>MMP1 gene may play a role in local invasion of OSCC, and can serve as a potential biomarker molecule for diagnosis, treatment and prognostic evaluation of OSCC, with also clinical value for OSCC classification.</p>
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Índice:
WPRIM
Asunto principal:
Patología
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ARN Mensajero
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Neoplasias de la Boca
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Carcinoma de Células Escamosas
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Regulación Enzimológica de la Expresión Génica
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Regulación Neoplásica de la Expresión Génica
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Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
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Metaloproteinasa 1 de la Matriz
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Genética
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Metabolismo
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2008
Tipo del documento:
Article