Clinical significance of changes in quantitative expression of human leukocyte antigen DR in severely burned patients / 中华外科杂志
Chinese Journal of Surgery
;
(12): 766-769, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-340917
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical significance of kinetic changes in quantitative expression of human leukocyte antigen DR (HLA-DR) in severely burned patients.</p><p><b>METHODS</b>The blood samples of 77 extensively burned patients (>30% of total body surface area) were serially collected in the present study. The expression of HLA-DR on CD14(+) mononuclear cell surface in burned patients were quantified by flow cytometry (using monoclonal antibody, QuantiBRITETM Anti-HLA-DR PE(*)/Anti-Monocyte PerCP-Cy5.5) on days 1, 3, 5, 7, 14, 21 and 28 post burn.</p><p><b>RESULTS</b>The expressions of HLA-DR on CD14(+) mononuclear cell surface in severely burned patients were significantly lower than those in healthy volunteers from the first day post burn (P < 0.05), and the value of HLA-DR expression was negatively correlated with the burned area (r = -0.7232, P < 0.05). The expression of HLA-DR in patients complicated with multiple organ dysfunction syndrome (MODS) was persistently decreased following major burns, and it was significantly lower than that of non-MODS patients on days 3, 14, 21 and 28 post burn (P < 0.05). The incidence rate of MODS rose markedly along with the lowering of HLA-DR expression, accompanied with poorer prognosis.</p><p><b>CONCLUSIONS</b>Extensive burns could result in marked damage in expression of HLA-DR on CD14(+) mononuclear cell surface and immunologic dysfunction. Quantitative measurement of HLA-DR expression might be of significance in forecasting the development of MODS and prognosis in extensively burned patients.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Sangre
/
Quemaduras
/
Monocitos
/
Antígenos HLA-DR
/
Receptores de Lipopolisacáridos
/
Alergia e Inmunología
/
Citometría de Flujo
/
Metabolismo
/
Insuficiencia Multiorgánica
Tipo de estudio:
Estudio pronóstico
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Surgery
Año:
2007
Tipo del documento:
Artículo
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