Comparison of right atrial matrix metalloproteinase expression between patients with unstable angina and myocardial infarction / 中华心血管病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To compare right atrial structural remodeling and the expression of matrix metalloproteinase (MMP) and tissue inhibitors (TIMP) between patients with unstable angina (UA) and myocardial infarction (MI).</p><p><b>METHODS</b>Right atrial appendages were obtained from 18 patients with UA and 22 patients with MI undergoing coronary artery bypass grafting (CABG) operations. MMP-1, -3, -7, -9 and TIMP-1 protein expressions were detected by immunohistochemistry and RT-PCR. Echocardiography was performed before CABG.</p><p><b>RESULTS</b>The left and right atrial diameter, left ventricular diameter and mRNA levels of MMP-3, MMP-9 and TIMP-1 were significantly higher in MI group than those in UA group [LAD (40.8 +/- 4.2) mm vs. (33.1 +/- 5.1) mm, P < 0.01; RAD (44.1 +/- 6.8) mm vs. (28.8 +/- 6.0) mm, P < 0.01; LVEDD (48.9 +/- 6.0) mm vs. (39.7 +/- 7.1) mm, P < 0.05; MMP-3 0.39 +/- 0.18 vs. 0.28 +/- 0.07, P < 0.05; MMP-9 0.81 +/- 0.21 vs. 0.55 +/- 0.20, P < 0.01; TIMP-1 1.79 +/- 0.89 vs. 0.94 +/- 0.47, P < 0.01]. MMP-1, MMP-7 levels were similar between the 2 groups (MMP-1 0.14 +/- 0.06 vs. 0.10 +/- 0.08, P > 0.05; MMP-7 0.25 +/- 0.05 vs. 0.23 +/- 0.06, P > 0.05).</p><p><b>CONCLUSION</b>Right atrial up-regulation of MMP-3, MMP-9 and TIMP-1 levels may contribute to the right atrial structural remodeling in MI patients.</p>