Effects of low-dose aspirin on primary prevention of cardiovascular events: a systematic review / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 315-320, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-341226
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect and safety of low-dose aspirin for primary prevention of cardiovascular events.</p><p><b>METHODS</b>We searched for randomized controlled trials (RCT) in the following electronic databases MEDLINE, EMbase, the Cochrane Library (Issue 3, 2008), CBM, CNKI. Quality assessment and data extraction were conducted by two reviewers independently. All data were analyzed using Review Manager 4.2.</p><p><b>RESULTS</b>Six studies (TPT, HOT, PPP, WHS, POPADAD, J-PAD) involving a total of 72,466 participants met the inclusion criteria. Meta-analysis results showed that (1) Compared with placebo, the incidences of total cardiovascular events (RR = 0.85, 95% CI 0.80-0.92), stroke (RR = 0.87, 95% CI 0.77-0.98), nonfatal stroke (RR = 0.81, 95% CI 0.70-0.95) and transient ischemic attack (RR = 0.76, 95% CI 0.64-0.90) were significantly lower in low-dose aspirin group than those in placebo control group (all P < 0.05). (2) Nonfatal myocardial infarction (RR = 0.89, 95% CI 0.77-1.02), death from cardiovascular causes (RR = 0.98, 95% CI 0.86-1.13) and death from any cause (RR = 0.95, 95% CI 0.88-1.02) were similar between the 2 groups (all P > 0.05). (3) The risk of coronary heart disease was reduced in low-dose aspirin group in the elderly (RR = 0.81, 95% CI 0.70-0.94, P < 0.05). (4) The risk of bleeding was higher in low aspirin group compared to placebo group (RR = 1.15, 95% CI 1.12-1.18, P < 0.01).</p><p><b>CONCLUSIONS</b>Low-dose aspirin use could reduce the incidences of total cardiovascular events, stroke, nonfatal stroke and transient ischemic attack but increase the risk of bleeding, the incidence of nonfatal myocardial infarction, death from cardiovascular causes and death from any cause was not affected by low-dose aspirin use. Low-dose aspirin use was also significantly reduced the risk of coronary heart disease in the elderly.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Prevención Primaria
/
Inhibidores de Agregación Plaquetaria
/
Enfermedades Cardiovasculares
/
Ensayos Clínicos Controlados Aleatorios como Asunto
/
Aspirina
/
Resultado del Tratamiento
/
Usos Terapéuticos
/
Quimioterapia
Tipo de estudio:
Ensayo Clínico Controlado
/
Revisiones Sistemáticas Evaluadas
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Cardiology
Año:
2010
Tipo del documento:
Artículo
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