Preventive efficacy of ondansetron and granisetron for postoperative nausea and vomiting in high risk patients / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 445-448, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-341386
ABSTRACT
<p><b>OBJECTIVE</b>To compare the efficacy of ondansetron and granisetron in the prevention of postoperative nausea and vomiting (PONV) in high-risk patients.</p><p><b>METHODS</b>Totally 200 patients with three key risk factors for PONV (female, non-smoking and postoperative opioid use) were equally randomized into ondansetron group and granisetron group. Ondansetron (4 mg) or granisetron (3 mg) was intravenously administered upon the completion of surgery. The episodes of nausea and vomiting were observed for 24 hours after surgery.</p><p><b>RESULTS</b>A significantly greater proportion of patients in granisetron group achieved a complete response (i.e., no PONV or rescue medication) during the first 24 hours postoperatively versus those in ondansetron group (62.6% vs. 46.9%, respectively; P=0.048). There were no significant differences in terms of postoperative nausea incidences (42.9% vs. 34.3%, respectively), postoperative vomiting incidences (25.5% vs. 20.2%, respectively) and postoperative rescue anti-emetics incidences (19.4% vs. 15.2%, respectively) (P>0.05).</p><p><b>CONCLUSION</b>Granisetron is more effective than ondansetron in preventing PONV in high-risk patients during the first 24 hours postoperatively.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Método Doble Ciego
/
Resultado del Tratamiento
/
Ondansetrón
/
Granisetrón
/
Náusea y Vómito Posoperatorios
/
Usos Terapéuticos
/
Antieméticos
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio de etiología
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Acta Academiae Medicinae Sinicae
Año:
2011
Tipo del documento:
Artículo
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