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Prevention of platelet transfusion refractoriness and HLA alloimmunization by leukocyte filtered platelet transfusion: a meta analysis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 412-420, 2011.
Artículo en Chino | WPRIM | ID: wpr-341392
ABSTRACT
<p><b>OBJECTIVE</b>To compare and assess the effectiveness of leukocyte-filtered platelet and standard platelet concentrates transfusion in preventing platelet transfusion refractoriness (PTR) and human leukocyte antigen (HLA)-alloimmunization.</p><p><b>METHODS</b>Randomized controlled trials (RCTs) or quasi-RCTs comparing leukocyte-filtered platelet with standard platelet concentrates transfusion (up to December 31, 2009) were searched and identified from Medline, EMBASE, The Cochrane Library, and CBM. A meta-analysis was conducted with Cochrane Collaboration's RevMan 5. 0.</p><p><b>RESULTS</b>The search identified 558 citations in total, in which 7 articles in English were finally included in the meta-analysis. The analysis showed that compared with standard platelet concentrates transfusion, leukocyte-filtered platelet transfusion significantly decreased PTR [ RR = 0. 59, 95% CI (0. 42, 0. 82) , P = 0. 002 ] and HLA-alloimmunization [ RR = 0. 49,95% CI (0. 33, 0. 74) , P =0. 0006]. Subgroup analysis showed that HLA-alloimmunization was significantly reduced by leukocyte-filtered platelet transfusion among the patients with acute myelocytic leukemia [ RR =0.42, 95% CI (0.32, 0.56), P <0. 00001], while no significant difference was detected in patients with acute lymphoblastic leukemia because of the limited sample size [ RR = 0. 50, 95% CI (0. 10, 2.41) , P =0. 39].</p><p><b>CONCLUSIONS</b>The current evidence shows that leukocyte-filtered platelet transfusion can prevent PTR and HLA-alloimmunization more effectively than standard platelet transfusion. Well-designed large-scale RCTs are still needed to further confirm this finding.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Ensayos Clínicos Controlados Aleatorios como Asunto / Transfusión de Plaquetas / Alergia e Inmunología / Filtración / Antígenos HLA / Leucocitos / Métodos Tipo de estudio: Ensayo Clínico Controlado / Estudio pronóstico / Revisiones Sistemáticas Evaluadas Límite: Humanos Idioma: Chino Revista: Acta Academiae Medicinae Sinicae Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Ensayos Clínicos Controlados Aleatorios como Asunto / Transfusión de Plaquetas / Alergia e Inmunología / Filtración / Antígenos HLA / Leucocitos / Métodos Tipo de estudio: Ensayo Clínico Controlado / Estudio pronóstico / Revisiones Sistemáticas Evaluadas Límite: Humanos Idioma: Chino Revista: Acta Academiae Medicinae Sinicae Año: 2011 Tipo del documento: Artículo