Research on a novel method for the evaluation of left ventricular diastolic function / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 270-273, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-341637
ABSTRACT
The methods for evaluating left ventricular diastolic function completely and simply are lacking in our country at present. To solve this problem, we presents in this paper a novel method, which is developed according to certain algorithms and mathematic models and is carried out by a MATLAB program. This method mainly obtains dP/dt loops, and calculates four important indices, including left ventricular end-diastolic pressure (LVEDP), Maximal decrease in velocity of left ventricular pressure (--(dP/dt)max), Time constant of ventricular isovolumic relaxation (tau) and Chamber stiffness (Kd), according to the changes of left ventricular pressure. The results obtained from the experiment of isolated rat hearts during ischemia/reperfusion have demonstrated the usefulness and validity of this method. Therefore, with the use of tau and Kd as indicators, this is a sensitive and effective method for evaluating the left ventricular diastolic function, and it can be applied to early detection of left ventricular diastolic dysfunction.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Presión Sanguínea
/
Técnicas In Vitro
/
Algoritmos
/
Daño por Reperfusión
/
Función Ventricular Izquierda
/
Ratas Sprague-Dawley
/
Disfunción Ventricular Izquierda
/
Diagnóstico
/
Diástole
Tipo de estudio:
Estudio diagnóstico
/
Estudio de tamizaje
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Biomedical Engineering
Año:
2010
Tipo del documento:
Artículo
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