The effects of hypoxic-ischemia on glutamate transporters / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 202-205, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-341653
ABSTRACT
Glutamate is a kind of excitatory transmitter in the central nervous system of mammals; at the same time, being with excitatory toxicity, its extracellular concentration is mainly modulated by the glutamate transporters. In the case of hypoxic-ischemia, the energy failure would lead to the generation of lactate and free radical, and to the crash of [Na+] gradient, thus exerting influence on the activity and the expression of glutamate transporters. As a result, the glutamate accumulates in the synaptic cleft, activates the glutamate receptors, and causes the death of neurons.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Sinapsis
/
Transmisión Sináptica
/
Ácido Glutámico
/
Hipoxia-Isquemia Encefálica
/
Sistema de Transporte de Aminoácidos X-AG
/
Proteínas de Transporte de Glutamato en la Membrana Plasmática
/
Metabolismo
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Journal of Biomedical Engineering
Año:
2010
Tipo del documento:
Artículo
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