Preparation and release exam of magnetic chitosan nano-spheres of doxorubicin / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 86-90, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-341676
ABSTRACT
Magnetic chitosan (CS) nano-spheres were prepared by the modified suspension cross-linking technique. The results demonstrated that the magnetic drug nano-spheres are mainly spherical in form with a size of 200 to 800 nm, and show good magnetic responsivity. Here, Doxorubicin was used as exam drug. Glutaraldehyde connects Doxorubicin to CS by the chemical bond (-N = C-), and the drug content is in range of 1% to 15% (w/w). The chemical bond is broken depending on pH, so pH is the important factor for the release of doxorubicin. The doxorubicin release was 22.0%, 13.4%, and 4.1% in the space of 7d, when pH was 1, 2, 4. So the nano-spheres are pH-sensitive magnetic targeting drug micro-spheres.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Portadores de Fármacos
/
Doxorrubicina
/
Química
/
Sistemas de Liberación de Medicamentos
/
Quitosano
/
Nanosferas
/
Magnetismo
/
Métodos
Idioma:
Chino
Revista:
Journal of Biomedical Engineering
Año:
2010
Tipo del documento:
Artículo
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