Expressions of bFGF, ET-1 and SCF in dermal papilla cells and the relation to their biological properties / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the expression of bFGF, ET-1 and SCF in different passages of cultured dermal papilla cells (DPC), and their possible effect on biological behaviour of DPC.</p><p><b>METHODS</b>The expression of bFGF, ET-1 and SCF in different passages of cultured DPC was detected by immunocytochemistry and in situ hybridization.</p><p><b>RESULT</b>The expression of ET-1 and SCF in early passages of cultured DPC was stronger, but became negative in late passages (>6 passages). The stronger the expression of ET-1 and SCF in DPC, the higher ability of DPC to induce hair follicle regeneration.</p><p><b>CONCLUSION</b>The expression strength of ET-1 and SCF is related to the ability of DPC inducing hair follicle regeneration.</p>