Effects between the first-and second-generation histamine H1-antagonists on seizure development of pentylenetetrazole-induced kindling in rats / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 209-212, 2004.
Article
en Zh
| WPRIM
| ID: wpr-341905
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects and the mechanisms of the first-generation histamine H(1)-antagonist diphenhydramine and the second-generation histamine H(1)- antagonist fexofenadine on seizure development of pentylenetetrazole (PTZ)-induced kindling in rats.</p><p><b>METHODS</b>The first-or second-generation histamine H(1)-antagonists and/or histidine were ip injected in rats every 48 h, followed by a subconvulsive dose of PTZ (35 mg/kg). Then the behavioral changes were observed for 30 min after every injection of PTZ. The histamine content of brain was measured spectrofluorometrically.</p><p><b>RESULT</b>Compared with the control group, diphenhydramine (5 mg/kg) significantly augmented the severity of seizure development of PTZ-induced kindling, whereas fexofenadine (5 mg/kg) had no marked influence. The effects of diphenhydramine were antagonized by histidine, the precursor of histamine.</p><p><b>CONCLUSION</b>Seizure development of PTZ-induced kindling is promoted by the first-but not the second generation histamine H(1)-antagonists via the blockade of brain histamine H(1)-receptor.</p>
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Asunto principal:
Pentilenotetrazol
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Farmacología
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Fisiología
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Convulsiones
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Histamina
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Ratas Sprague-Dawley
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Antagonistas de los Receptores Histamínicos H1 no Sedantes
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Antagonistas de los Receptores Histamínicos H1
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Histidina
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Excitación Neurológica
Límite:
Animals
Idioma:
Zh
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2004
Tipo del documento:
Article