Your browser doesn't support javascript.
loading
Distribution of hepatitis B virus genotype in 5 cities of Fujian province and the clinical implications of HBV genotype / 中华流行病学杂志
Chinese Journal of Epidemiology ; (12): 251-255, 2004.
Artículo en Chino | WPRIM | ID: wpr-342342
ABSTRACT
<p><b>OBJECTIVE</b>To study the prevalence of hepatitis B virus (HBV) genotype in 5 cities of Fujian province and the clinical implications of distinct genotypes in HBV-related liver diseases.</p><p><b>METHODS</b>HBV genotype was determined by the restriction fragment length polymorphism analysis in patients with chronic HBV infection in 5 cities of Fujian province. The relationship between HBV genotype and its clinical implications was studied by multinomal logistic regression and correspondence analysis.</p><p><b>RESULTS</b>Of the 431 HBV DNA positive patients detected by PCR, 275 (63.8%) belonged to HBV genotype B, 100 (23.2%) to genotype C, 51 (11.8%) to genotype D and D-mixed genotype. Genotype A, E and F were not found. Multinomal logistic regression showed that genotype B was more prevalent in Quanzhou and Sanming cities than in Fuzhou (P = 0.002, P = 0.006), and genotype B appeared significantly more common in asymptomatic carriers (ASC), chronic hepatitis B (CHB) and severe hepatitis (SH). Genotype C was most prevalent in patients with liver cirrhosis (LC) (47.0%) than in those with ASC (14.5%) and SH (14.7%) (P = 0.009, P < 0.001). The positive rate of hepatitis B e antigen was higher in patients with genotype C than in those with genotype B and genotype D (56.0% vs. 52.4%, P = 0.008, and 56.0% vs. 30.8%, P = 0.051, respectively). By correspondence analysis, genotype D and D-mixed genotype seemed to be correlated with hepatocellular carcinoma (HCC).</p><p><b>CONCLUSIONS</b>(1) The major popular genotypes of HBV were B, C and D in Fujian. (2) Data of our study suggested that the geographic distribution of genotype B and C might be different in some cities of Fujian. (3) Genotype B might have a tendency to lead to SH in younger patients with chronic hepatitis B and the development of LC might be associated with genotype C among the elder patients. (4) Genotype D appeared to associate with development of HCC, which called for further study to confirm.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Virología / Polimorfismo de Longitud del Fragmento de Restricción / Modelos Logísticos / China / Virus de la Hepatitis B / Reacción en Cadena de la Polimerasa / Análisis Multivariante / Frecuencia de los Genes / Genética / Genotipo Tipo de estudio: Estudio pronóstico / Factores de riesgo Límite: Adolescente / Adulto / Anciano / Niño / Child, preschool / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Chino Revista: Chinese Journal of Epidemiology Año: 2004 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Virología / Polimorfismo de Longitud del Fragmento de Restricción / Modelos Logísticos / China / Virus de la Hepatitis B / Reacción en Cadena de la Polimerasa / Análisis Multivariante / Frecuencia de los Genes / Genética / Genotipo Tipo de estudio: Estudio pronóstico / Factores de riesgo Límite: Adolescente / Adulto / Anciano / Niño / Child, preschool / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Chino Revista: Chinese Journal of Epidemiology Año: 2004 Tipo del documento: Artículo