Progress in the structure and function of human carboxylesterase 1 / 生物工程学报
Chinese Journal of Biotechnology
; (12): 1414-1422, 2012.
Article
en Zh
| WPRIM
| ID: wpr-342385
Biblioteca responsable:
WPRO
ABSTRACT
Human carboxylesterase 1 (HCE1), belonging to a multigene serine hydrolase family, is a major liver carboxylesterase responsible for the hydrolysis and metabolism of various xenobiotics. It also plays an important role in the transportation and metabolism of endogenous cholesterol ester and free fatty acid, and is closely associated with the pathogenesis of hepatocellular carcinoma. This review describes current developments in the molecular structure, the roles in drug, toxins and lipid metabolism, and the early diagnosis for hepatocellular carcinoma of human carboxylesterase 1.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Fisiología
/
Hidrolasas de Éster Carboxílico
/
Xenobióticos
/
Ésteres del Colesterol
/
Carcinoma Hepatocelular
/
Diagnóstico
/
Ácidos Grasos no Esterificados
/
Genética
/
Neoplasias Hepáticas
/
Metabolismo
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Límite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Biotechnology
Año:
2012
Tipo del documento:
Article