Induced pluripotent stem cells generated from reprogramming differentiated cells by defined factors / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1121-1127, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-342781
ABSTRACT
Embryonic stem cell is promising for regenerative medicine. However, its application is hampered by the utilization of eggs in most established methods. Recently, a new pluripotent stem cell establishing method was reported that, mouse and human differentiated cells could be induced reprogrammed into a pluripotent state by expressing exogenetic stem factors such as Oct4, Sox2, et al, through retroviral transduction. This approach avoiding egg use is a great breakthrough not only in stem cell technology but also present theory hypothesis of reprogramming. Here these works were reviewed in this article. Both the mechanism of induced reprogramming and the prospects of induced pluripotent stem cells were discussed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Retroviridae
/
Transducción Genética
/
Diferenciación Celular
/
Células Cultivadas
/
Biología Celular
/
Células Madre Pluripotentes
/
Factor 3 de Transcripción de Unión a Octámeros
/
Reprogramación Celular
/
Factores de Transcripción SOXB1
/
Genética
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Biotechnology
Año:
2008
Tipo del documento:
Artículo
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