Regulatory genes of geldanamycin biosynthesis / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 717-722, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-342845
ABSTRACT
Two LAL family regulatory genes, gdmRI and gdmRII, were identified in the geldanamycin biosynthetic gene cluster of Streptomyces hygroscopicus 17997. Disruption of the two regulatory genes resulted in absolute elimination of geldanamycin biosynthesis. The complementation experiments using a single wild-type gene could restore geldanamycin production. These results indicated that both gdmRI and gdmRII were positive regulatory genes of the geldanamycin biosynthesis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteínas Represoras
/
Streptomyces
/
Proteínas Tirosina Quinasas
/
Regulación Bacteriana de la Expresión Génica
/
Transactivadores
/
Benzoquinonas
/
Proteínas HSP90 de Choque Térmico
/
Lactamas Macrocíclicas
/
Genética
/
Metabolismo
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
Chinese Journal of Biotechnology
Año:
2008
Tipo del documento:
Artículo
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