Application of benchmark dose (BMD) in a bone-effect study on a general population environmentally exposed to cadmium / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
; (12): 23-26, 2006.
Article
en Zh
| WPRIM
| ID: wpr-343077
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To estimate the benchmark dose for osteoporosis caused by cadmium exposure in a Chinese general population with an epidemiological study.</p><p><b>METHODS</b>The inhabitants living in both cadmium polluted and non-polluted areas served as the exposure group and the control group. Urinary cadmium (UCd) and Blood cadmium (BCd) were used as exposure biomarkers while the Z score was used as effect biomarker for the osteoporosis.</p><p><b>RESULTS</b>The UCd and BCd in the habitants of the polluted areas were significantly higher than those in the habitants of the control area on average (P < 0.05) and the UCd and BCd in the habitants of the highly polluted areas were significantly higher than those in the habitants of the moderately polluted area on average (P < 0.05). The bone mineral density was significantly decreased in the groups of the highest UCd and BCd level compared with the 5 microg/g Cr group with the significant difference (P < 0.05). The morbidity of the osteoporosis would increase significantly with the increase of the cadmium exposure (P < 0.05) with the linear correlation (P < 0.05). BMDs were calculated using BMDS Version l.3.2 software and BMDLs were also determined. The BMDL of UCd for cadmium-induced osteoporosis was higher than those representing cadmium-induced renal dysfunction.</p><p><b>CONCLUSION</b>High level of cadmium exposure can induce osteoporosis, which occurs later than renal damage related to cadmium exposure. The BMD is a practical method.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Osteoporosis
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Cadmio
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Densidad Ósea
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China
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Epidemiología
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Relación Dosis-Respuesta a Droga
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Exposición a Riesgos Ambientales
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Metabolismo
Límite:
Aged
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Female
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Año:
2006
Tipo del documento:
Article