Decreased Expression of 15-hydroxyprostaglandin Dehydrogenase in Gastric Carcinomas
Yonsei Medical Journal
;
: 917-922, 2008.
Artículo
en Inglés
| WPRIM
| ID: wpr-34313
ABSTRACT
PURPOSE:
Gastric carcinoma tissues release high level of prostaglandin E2 (PGE2) when compared to non-neoplastic mucosa, and cyclooxygenase-2 (COX-2), which is the rate-limiting enzyme in prostaglandin (PG) biosynthesis, is often overexpressed in gastric carcinomas and during gastric carcinogenesis. However, little is known about the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the key enzyme responsible for the biological inactivation of PG, in gastric carcinomas. MATERIALS ANDMETHODS:
We investigated the expression of 15-PGDH in 28 cases of advanced gastric carcinomas by Western blot analysis and also the relation between its expression and the gene promoter methylation.RESULTS:
15-PGDH expression was significantly decreased in gastric carcinomas compared to corresponding non-neoplastic tissues and inversely correlated with the expression of proliferating cell nuclear antigen in gastric carcinomas. However, there was no correlation between 15-PGDH expression and pathological findings such as nodal metastasis and vascular invasion. Promoter hypermethylation of 15-PGDH gene was not detected in carcinomas, with only a negligible expression of the enzyme.CONCLUSION:
Our results suggested that 15-PGDH has tumor suppressor activity in gastric carcinomas.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Gástricas
/
ADN de Neoplasias
/
Secuencia de Bases
/
Hidroxiprostaglandina Deshidrogenasas
/
Regiones Promotoras Genéticas
/
Cartilla de ADN
/
Metilación de ADN
Límite:
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Yonsei Medical Journal
Año:
2008
Tipo del documento:
Artículo
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