Anti-elastase, anti-tyrosinase and matrix metalloproteinase-1 inhibitory activity of earthworm extracts as potential new anti-aging agent
Asian Pacific Journal of Tropical Biomedicine
;
(12): S348-52, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-343255
ABSTRACT
<p><b>OBJECTIVE</b>To examine whether earthworms of Eisenia fetida, Lumbricus rubellus and Eudrilus eugeniae extracts have elastase, tyrosinase and matrix metalloproteinase-1 (MMP-1) inhibitory activity.</p><p><b>METHODS</b>The earthworms extract was screened for elastase, tyrosinase and MMP-1 inhibitory activity and compared with the positive controls. It was also evaluated for whitening and anti-wrinkle capacity.</p><p><b>RESULTS</b>The extract showed significantly (P<0.05) good elastase and tyrosinase inhibition and excellent MMP-1 inhibition compared to N-Isobutyl-N-(4-methoxyphenylsulfonyl)-glycylhydroxamic acid.</p><p><b>CONCLUSIONS</b>Earthworms extract showed effective inhibition of tyrosinase, elastase and MMP-1 activities. Therefore, this experiment further rationalizes the traditional use of this worm extracts which may be useful as an anti-wrinkle agent.</p>
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Inglés
Revista:
Asian Pacific Journal of Tropical Biomedicine
Año:
2014
Tipo del documento:
Artículo
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