Study on water of crystallization in tazobactam / 药学学报

ABSTRACT

<p><b>AIM</b>To investigate whether tazobctam has crystallization water.</p><p><b>METHODS</b>In order to establish a method for water content determination in tazobctam, many methods including Karl Fischer titration, weight loss on drying, TGA, DSC and X-ray diffraction experiment of an orthorhombic form were studied.</p><p><b>RESULTS</b>The water content of the same batch tazobactam determined by different mthods was different.</p><p><b>CONCLUSION</b>The results showed that one mole tazobatam contains half mole water of crystallization and the strength of attraction between tazobatam molecule and water molecule is rather strong.</p>