Anti-gastric ulcer sesquiterpene lactone glycosides from Crepis napifera / 药学学报

ABSTRACT

<p><b>AIM</b>The anti-gastric ulcer constituents from the roots of Crepis napifera (Franch) Babc (Compositae) were studied.</p><p><b>METHODS</b>Solvent partition, Si gel and Rp-18 column chromatography, crystallization and spectral methods were used to extract, isolate and identify two compounds. The activity of compound 1 was tested on the rat stomach by determining the effect on aspirin-induced gastric lesions and on histamine-stimulated gastric acid secretion.</p><p><b>RESULTS</b>Two sesquiterpene lactone glycosides, taraxinic acid-1'-O-beta-D-glucopyranoside (1) and 11,13-dihydro-taraxinic acid-1'-O-beta-D-glucopyranoside (2) were obtained. Compound 1 at the dose of 80 mg.kg-1 p.o. inhibited significantly the development of aspirin-induced gastric lesions in the rat and at an i.v. dose of 70 mg.kg-1 did not affect histamine-stimulated gastric acid secretion in the lumen-perfused rat stomach.</p><p><b>CONCLUSION</b>Compound 1 is the active component of the plant which protects gastric mucosa and exhibits anti-gastric ulcer action.</p>