Effects of prostate water pellets on the serum levels of IL-6 and TNF-alpha in rats with chronic bacterial prostatitis / 中华男科学杂志
National Journal of Andrology
;
(12): 470-472, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-343595
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of Prostate Water Pellets (PWP) on serum levels of IL-6 and TNF-alpha in rats with chronic bacterial prostatitis (CBP).</p><p><b>METHODS</b>Fifty healthy, adult, male Wistar rats with the weight of 180 - 220 g were divided into five groups of ten rats each at random the control group, model group, high dosage of PWP group, low dosage of PWP group and levofloxacin group. The CBP rat model were created by injecting Escherichia coli (0.2 ml/rat, 10(7)/ml) into prostates. A month later after the model creation, high and low dosage of PWP suspension were used by gavage in CBP rats for 30 days, respectively. Levofloxacin tablets were used by gavage as the positive control, and distilled water was used by gavage in the control and model group. After thirty days, serum levels of IL-6 and TNF-alpha were measured with radioimmunoassay.</p><p><b>RESULTS</b>Compared with the model group, serum levels of IL-6 and TNF-alpha of rats in high and low dosage PWP groups were lower and the difference was significant statistically (P < 0.01).</p><p><b>CONCLUSION</b>It has effect to treat CBP rat with the PWP and its mechanism may relate with the decreasing levels of proinflammatory cytokines(IL-6 and TNF-alpha) in blood.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Prostatitis
/
Infecciones Bacterianas
/
Sangre
/
Medicamentos Herbarios Chinos
/
Distribución Aleatoria
/
Enfermedad Crónica
/
Interleucina-6
/
Factor de Necrosis Tumoral alfa
/
Ratas Wistar
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
National Journal of Andrology
Año:
2006
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS