Altered expression of the HSD17B4 gene in esophageal squamous cell carcinoma and loss of heterozygosity analysis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 270-273, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-343724
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the alteration of the gene HSD17B4 in esophageal squamous cell carcinoma and its potential significance.</p><p><b>METHODS</b>The mRNA expression and loss of heterozygosity (LOH) of HSD17B4 in 40 primary esophageal tumors were detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and microsatellite analysis with the intragenic marker D5S1384 of the gene.</p><p><b>RESULTS</b>The frequencies of allelic loss of D5S1384 and the rate of down-regulation of gene HSD17B4 were 46.2% and 62.5%, respectively.</p><p><b>CONCLUSION</b>HSD17B4 may be a candidate tumor suppressor gene associated with esophageal squamous cell carcinoma.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
ARN Mensajero
/
Neoplasias Esofágicas
/
Carcinoma de Células Escamosas
/
Regulación hacia Abajo
/
Expresión Génica
/
Regulación Neoplásica de la Expresión Génica
/
Genes Supresores de Tumor
/
Repeticiones de Microsatélite
/
Pérdida de Heterocigocidad
/
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Acta Academiae Medicinae Sinicae
Año:
2005
Tipo del documento:
Artículo
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