Bcl-2/Bax gene expression in different types of carotid plaque / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 241-244, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-343731
ABSTRACT
<p><b>OBJECTIVE</b>To investigate Bcl-2/Bax gene expression in different types of carotid plaque, and examine the relationship between gene expression and atherosclerotic plaque instability and the main cause of brain ischemic events.</p><p><b>METHODS</b>Totally 42 human carotid plaque specimens obtained during carotid endarterectomy were divided into stable group (n=19) and unstable group (n=23) based on histopathological studies (HE staining). Eight aortic arteries and their branches from hepatic transplantation donors were taken as control group. Bcl-2/Bax was detected by immunohistochemistry (IHC) staining (n=42) and in situ hybridization (ISH) (n=25, stable 13/unstable 12).</p><p><b>RESULTS</b>Bcl-2 gene expression, which was expressed in smooth muscle cells (SMC), endothelial cells (EC), macrophages (MP) and foam cells, was detected in 20 and 9 cases in unstable plaque while 11 and 4 cases in stable plaque by IHC and ISH, respectively (P < 0.05). Bax, which was expressed in SMC and MP, was detected in 18 and 11 cases in unstable plaque, while 8 and 5 cases in stable plaque by IHC and ISH, respectively (P < 0.05).</p><p><b>CONCLUSION</b>The expression rate of Bcl-2/Bax in unstable plaques was higher than in stable plaques. Bcl-2 was one of the elements that maintain plaque stability whereas Bax was one element that facilitates plaque instability. Therefore, Bcl-2/Bax expression in different stage of atherosclerosis may be one of the molecule regulation mechanisms in carotid atherosclerosis.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Endotelio Vascular
/
Arterias Carótidas
/
Enfermedades de las Arterias Carótidas
/
Regulación hacia Arriba
/
Estenosis Carotídea
/
Apoptosis
/
Proteínas Proto-Oncogénicas c-bcl-2
/
Proteína X Asociada a bcl-2
/
Genética
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Academiae Medicinae Sinicae
Año:
2005
Tipo del documento:
Artículo
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