LEDGF/p75: a novel target for anti-HIV therapy and advances in the study of its related inhibitors / 药学学报
Acta Pharmaceutica Sinica
;
(12): 953-960, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-344013
ABSTRACT
LEDGF/p75 is a newly found cell cofactor, which plays an essential role in the integration of HIV-1 cDNA into host chromosomes. LEDGF/p75 tethers HIV integrase to chromatin, protects it from degradation, and strongly influences the genome-wide pattern of HIV integration. Depleting the protein from cells or over-expressing the integrase-binding domain of LEDGF/p75 blocks viral replication. The essential role of LEDGF/p75 in HIV-1 replication makes it a new target for anti-HIV-1 drug development. This article reviews the function of LEDGF/p75, LEDGF/p75-integrase interaction and LEDGF/p75 inhibitors.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fisiología
/
Unión Proteica
/
Química
/
VIH-1
/
Integrasa de VIH
/
Fármacos Anti-VIH
/
Péptidos y Proteínas de Señalización Intercelular
/
Metabolismo
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2009
Tipo del documento:
Artículo
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