Bradykinin modulates ion channel in inflammatory pain / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1066-1071, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-344055
ABSTRACT
Injury or inflammation induces release of a range of inflammatory mediators. Bradykinin is one of the most important inflammatory mediators and plays a crucial role in mediating inflammatory pain. It is well known that multiple ion channels located in the nociceptors participate in pain sensation. Recent studies demonstrate an important role of bradykinin in regulating the function and expression of pain-related ion channels. This paper summarizes the recent advances in the understanding of the role of bradykinin in modulation of the channels and discusses future possibilities in the treatment of inflammatory pain.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Dolor
/
Farmacología
/
Fisiología
/
Bradiquinina
/
Canales de Sodio
/
Receptores de N-Metil-D-Aspartato
/
Receptores AMPA
/
Mediadores de Inflamación
/
Canales de Potasio KCNQ
/
Canales de Potencial de Receptor Transitorio
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2009
Tipo del documento:
Artículo
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