Anti-tumor activity of Erythrina variegata L. extract and its mechanism of action / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1359-1363, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-344071
ABSTRACT
The anti-tumor activities and mechanism of Erythrina variegata L. extract were investigated. Firstly, the MTT method was used to evaluate the inhibitory activity of the Erythrina variegata L. extract on proliferation of cancer cell lines. Moreover, in order to determine its anti-tumor effect in vivo, the Lewis lung cancer mice model was established. By comparing the relative tumor proliferation rates, growth curves, inhibition rates of different groups, the anti-tumor effect was evaluated. Furthermore, the anti-tumor mechanism of Erythrina variegata L. extract was studied by using G-quadruplex stability experiment. In the in vitro anti-liver cancer experiment, the Erythrina variegata L. extract has shown obvious anti-tumor effect on various tumor cells. And in the in vivo experiment, it exhibited significant anti-tumor effect. Besides, from the result of G-quadruplex stability experiment, we can see that the quadruplex structure show increasing T(m) values with increasing amounts of Erythrina variegata L. extract.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Plantas Medicinales
/
Medicamentos Herbarios Chinos
/
Química
/
Carcinoma Pulmonar de Lewis
/
Línea Celular Tumoral
/
Carga Tumoral
/
Proliferación Celular
/
Erythrina
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2009
Tipo del documento:
Artículo
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