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Expression of tumor-specific cancer/testis antigens in hepatocellular carcinoma / 中华肝脏病杂志
Chinese Journal of Hepatology ; (12): 145-148, 2003.
Artículo en Chino | WPRIM | ID: wpr-344480
ABSTRACT
<p><b>OBJECTIVE</b>(1) To investigate the expression and gene diversity of the 7 major cancer/testis (CT) antigens, MAGE-1, MAGE-3, MAGE-4, MAGE-10, NY-ESO-1, SSX-2 and SCP-1, in hepatocellular carcinoma (HCC). (2) To analyze the correlations between the clinical characters and CT antigens' expression.</p><p><b>METHODS</b>The cancer and para-cancer tissues were collected from 30 HCC patients. The mRNAs of seven CT antigens were detected by reverse transcription-polymerase chain reaction (RT-PCR) with the specific primers. The PCR products were sequenced to analyze the CT genes.</p><p><b>RESULTS</b>The MAGE-1, MAGE-3, MAGE-4, MAGE-10, NY-ESO-1, SSX-2 and SCP-1 were expressed in 66.7%, 70.0%, 20.0%, 36.7%, 40.0%, 33.3% and 33.3% of the tumor tissues from HCC patients respectively, however, they were not expressed in the para-cancer tissues. Among the 30 patients investigated, 90.0% expressed one CT gene at least, 70.0% expressed two CT genes, and 53.3% expressed three CT genes of the seven CT genes. The coding genes of these CT antigens were highly conserved between in Chinese patients and patients abroad. There were discernible correlations between alpha-fetoprotein level and MAGE-10 or SCP-1 expression level, as well as between average age and MAGE-3 or SSX-2 expression levels (P<0.05).</p><p><b>CONCLUSIONS</b>With a highly conserved coding gene, seven CT antigens were expressed in 20.0% - 70.0% of Chinese HCC patients. CT antigens' expression had correlations with some clinical characters.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: ARN Mensajero / Regulación Neoplásica de la Expresión Génica / Carcinoma Hepatocelular / Alergia e Inmunología / Antígenos Específicos del Melanoma / Genética / Neoplasias Hepáticas / Antígenos de Neoplasias / Proteínas de Neoplasias Límite: Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Hepatology Año: 2003 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: ARN Mensajero / Regulación Neoplásica de la Expresión Génica / Carcinoma Hepatocelular / Alergia e Inmunología / Antígenos Específicos del Melanoma / Genética / Neoplasias Hepáticas / Antígenos de Neoplasias / Proteínas de Neoplasias Límite: Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Hepatology Año: 2003 Tipo del documento: Artículo