Effect of several penetration enhancers on transdermal absorption in vitro of syringin, chologenic acid and rutin in Xuelian cataplasm / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1661-1664, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-344562
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of different penetration enhancers on the transcutaneous permeability of syringin, chologenic acid and rutin in Xuelian cataplasm in vitro and to determine the effective enhancer.</p><p><b>METHOD</b>Using improved Franz-type diffusion cell and excised big mouse skin in vitro as transdermal barrier, the kinetics parameters of syringin, chologenic acid and rutin in Xuelian cataplasm such as cumulative permeation quantity, permeation rate were determined by HPLC. The enhancement ability of azone (A-zone), propylene glycol (PG) was investigated when used either uniquely or combinatively.</p><p><b>RESULT</b>With the 7% azone, the syringin, chologenic acid and rutin in Xuelian cataplasm could penetrate through the skin of rats well.</p><p><b>CONCLUSION</b>The selection of the best penetration enhancers provide reference for Xuelian cataplasm.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Permeabilidad
/
Fenilpropionatos
/
Rutina
/
Absorción Cutánea
/
Técnicas In Vitro
/
Portadores de Fármacos
/
Medicamentos Herbarios Chinos
/
Farmacocinética
/
Química
/
Propilenglicol
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2009
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS