Association of the Catechol O-Methyltransferase Val158-Met Polymorphism and Reduced Interference Control in Korean Children with Attention-Deficit Hyperactivity Disorder
Psychiatry Investigation
;
: 563-565, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-34500
ABSTRACT
OBJECTIVE:
We tested for association of the catechol-O-methyltransferase (COMT) Val158-Met (rs4680) polymorphism with attention-deficit hyperactivity disorder (ADHD) using family-based test in Korean trios.METHODS:
A total of 181 subjects with ADHD along with both of their biological parents were recruited from University Hospitals in Korea. We performed a transmission disequilibrium test (TDT) on 181 trios.RESULTS:
In the TDT, we found the over-transmission of the Val allele in children with ADHD (chi2=4.21, p=0.040).CONCLUSION:
These results suggest that the COMT Val158-Met polymorphism is associated with ADHD among the Korean population. However, this study must be replicated in larger populations.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Padres
/
Catecol O-Metiltransferasa
/
Alelos
/
Hospitales Universitarios
/
Corea (Geográfico)
Límite:
Niño
/
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Psychiatry Investigation
Año:
2015
Tipo del documento:
Artículo
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