Relationship between various Chinese medicine types and T-cell subsets in patients with ulcerative colitis / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 220-223, 2009.
Artículo
en Inglés
| WPRIM
| ID: wpr-345010
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between various Chinese medicine (CM) types and T-cell subsets (CD4(+) and CD8(+)) in the colonic mucous membranes of patients with ulcerative colitis (UC).</p><p><b>METHODS</b>Fifty UC patients were enrolled, after differentiation into four types by CM syndromes, i.e., the internal heat-damp accumulation type (IHDA), the qi-stagnancy with blood stasis type (QSBS), the Pi-Shen yang-deficiency type (PSYD) and the yin-blood deficiency type (YBD). From every patient, 3-5 pieces of intestinal mucous membrane tissues were taken through colonoscopy to determine the levels of the T-cell subsets (CD4(+) and CD8(+)) using immunohistochemical method. The results were compared with those in the normal control.</p><p><b>RESULTS</b>The level of CD8(+)increased and the ratio of CD4(+)/CD8(+)decreased mainly in colonic mucous membranous tissues in UC patients. The level of CD4(+)decreased significantly in IHDA types (P<0.01), but decreased only slightly in the PSYD, QSBS and YBD types. CD8(+)increased significantly in the IHDA types (P<0.01), but only slightly in the other three types.</p><p><b>CONCLUSION</b>The IHDA types of UC are closely related with T-cell subsets. The difference of T-cell subsets in various IHDA types of UC patients has provided a theoretical basis for syndrome differentiation in the CM typing of UC.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Biopsia
/
Circulación Sanguínea
/
Inmunohistoquímica
/
Colitis Ulcerosa
/
Subgrupos de Linfocitos T
/
Colonoscopía
/
Deficiencia Yin
/
Deficiencia Yang
/
Relación CD4-CD8
Tipo de estudio:
Estudio diagnóstico
Límite:
Adolescente
/
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Chinese journal of integrative medicine
Año:
2009
Tipo del documento:
Artículo
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