Association of polymorphisms in testosterone 5-alpha-reductase II genotype and prognosis factors of prostate cancer / 中华外科杂志
Chinese Journal of Surgery
;
(12): 1493-1496, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-345058
ABSTRACT
<p><b>OBJECTIVE</b>The correlation were studied between testosterone 5-alpha-reductase II (SRD5A2) gene polymorphisms and prognosis factors.</p><p><b>METHODS</b>V89L and A49T variants was identified with Mwo1 and Rsa1. The differences of V89L and A49T between cancer of prostate (CaP) and benign prostatic hyperplasia (BPH) were studied. In addition, we also researched the association of polymorphisms with age of onset, free prostate specific antigen (FPSA), total PSA (TPSA), FPSA/TPSA (F/T), Gleason score, and T stage in cancer group.</p><p><b>RESULTS</b>We found no differences of V89L and A49T polymorphisms between CaP and BPH. In CaP group the A49T variant was associated with lower age of onset (P = 0.03) and higher Gleason score (P = 0.015). There were no differences between VV and VL+LL polymorphisms with any of the characteristics studied. When the characteristics above were regarded as two-level discrete variable, there were no differences by A49T and V89Lvariants.</p><p><b>CONCLUSION</b>In CaP group, the AT+TT genotype was perhaps associated with poor prognosis. VL+LL genotype has no relation with prognosis.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Polimorfismo Genético
/
Pronóstico
/
Hiperplasia Prostática
/
Neoplasias de la Próstata
/
3-Oxo-5-alfa-Esteroide 4-Deshidrogenasa
/
Sangre
/
Antígeno Prostático Específico
/
Predisposición Genética a la Enfermedad
/
Frecuencia de los Genes
Tipo de estudio:
Estudio pronóstico
Límite:
Anciano
/
Aged80
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Surgery
Año:
2004
Tipo del documento:
Artículo
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