Influence of chromosomal polymorphisms on the clinical outcome of patients undergoing in vitro fertilization embryo transfer / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the influence of chromosome polymorphisms on the outcome of in vitro fertilization embryo transfer (IVF-ET).</p><p><b>METHODS</b>Patients who completed the first cycle of in vitro fertilization fresh embryo transfer were retrospective studied. Patients with the chromosome polymorphisms were classified as to the study group (200 treatment cycles), all patients with normal chromosomes at the same period were classified as the control group (4777 treatment cycles).</p><p><b>RESULTS</b>No significant difference was found between the chromosome polymorphisms and the control groups in terms of clinical pregnancy rate (44.50% vs. 39.85%, P=0.750), early abortion rate (15.73% vs. 10.79%, P=0.163) and live birth rate per cycle (34.5% vs. 30.73%, P=0.437) except for fertilization rate (60.94% vs. 64.08%, P=0.001), cleavage rate (95.01% vs. 97.09%, P=0.000) and good quality embryo rate (53.8% vs. 58.2%, P=0.001).</p><p><b>CONCLUSION</b>Chromosomal polymorphisms appeared to have no adverse influence on the outcome of IVF-ET treatment.</p>