Association of vascular endothelial growth factor gene polymorphisms with ectopic pregnancy among Chinese women / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 535-539, 2016.
Artículo
en Chino
| WPRIM
| ID: wpr-345414
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association of vascular endothelial growth factor (VEGF) gene polymorphisms with ectopic pregnancy (EP) among Chinese women.</p><p><b>METHODS</b>A case-control study was carried out, which compared 192 women with a history of EP with 210 post-menopausal controls who had two pregnancies but no history of EP for the genotypes of the VEGF gene. Polymorphisms of the VEGF gene including -460C/T, -1154G/A, -2578C/A and +936C/T were determined with a polymerase chain reaction-restriction fragment length polymorphism method.</p><p><b>RESULTS</b>No significant difference was found in the genotypic and allelic distribution of the -460C/T and +936C/T polymorphisms between the two groups. Compared with the GG genotype, the VEGF -1154 AA+GA genotype could significantly decrease the risk of EP (OR=0.61, 95%CI 0.42-0.87). Compared with the CC genotype, VEGF -2578 AA+CA genotype could significantly reduce the risk of EP (OR=0.66, 95%CI0.44-0.99). Haplotype analysis suggested that the T-A-A (VEGF -460/-1154/-2578) and C-A-A haplotypes could significantly decrease the risk of EP compared with the T-G-C haplotype (P=0.020, OR=0.41, 95%CI0.19-0.89, P=0.014, OR=0.29, 95%CI0.11-0.82).</p><p><b>CONCLUSION</b>The -1154A or -2578A alleles of the VEGF gene can significantly decrease the risk of EP among Chinese women. The VEGF -460C/T, -1154G/A and -2578C/A polymorphisms showed a linkage disequilibrium. Both T-A-A and C-A-A haplotypes can significantly decrease the risk of EP.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Embarazo Ectópico
/
Haplotipos
/
Estudios de Casos y Controles
/
Desequilibrio de Ligamiento
/
Riesgo
/
Polimorfismo de Nucleótido Simple
/
Factor A de Crecimiento Endotelial Vascular
/
Genética
/
Genotipo
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
/
Embarazo
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2016
Tipo del documento:
Artículo
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