Association between vitamin D receptor gene polymorphisms and pediatric Crohn's disease in China: a study based on gene sequencing / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1006-1008, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-345660
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between TaqI, BsmI, and ApaI polymorphisms of vitamin D receptor (VDR) gene and pediatric Crohn's disease (CD) in China.</p><p><b>METHODS</b>Nineteen children with CD were selected as a case group, and 122 healthy children who underwent physical examination were selected as a control group. Serum 25-hydroxyvitamin D3 [25(OH)D3] levels were measured using ELISA. The TaqI, BsmI, and ApaI polymorphisms of VDR gene were determined by gene sequencing, and the two groups were compared in terms of genotype and allele frequencies.</p><p><b>RESULTS</b>The case group had significantly lower serum 25(OH)D3 levels than the control group (17.3±2.4 ng/mL vs 26.9±2.1 ng/mL; P<0.05). There were no significant differences in the frequencies of genotypes and alleles of TaqI, BsmI, and ApaI polymorphisms between the case and control groups (P>0.05).</p><p><b>CONCLUSIONS</b>Children with CD have low serum 25(OH)D3 levels. TaqI, BsmI, and ApaI polymorphisms of VDR gene may not be associated with susceptibility to CD among the Chinese population.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sangre
/
Calcifediol
/
Enfermedad de Crohn
/
Análisis de Secuencia de ADN
/
Receptores de Calcitriol
/
Polimorfismo de Nucleótido Simple
/
Genética
Límite:
Adolescente
/
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Contemporary Pediatrics
Año:
2013
Tipo del documento:
Artículo
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