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Gemcitabine Plus Platinum Combination Chemotherapy for Elderly Patients with Advanced Non-small Cell Lung Cancer: A Retrospective Analysis / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 217-224, 2011.
Artículo en Inglés | WPRIM | ID: wpr-34651
ABSTRACT

PURPOSE:

This study aimed to analyze the efficacy and toxicity of gemcitabine plus platinum chemotherapy for patients aged 70 years or older with advanced non-small-cell lung cancer (NSCLC). MATERIALS AND

METHODS:

We reviewed the records of stage IIIB, IV NSCLC patients or surgically inoperable stage II, IIIA NSCLC patients who were aged 70 years or older when treated with gemcitabine (1,250 mg/m2) plus cisplatin (75 mg/m2) or carboplatin (AUC5) chemotherapy from 2001 to 2010 at Seoul St. Mary's Hospital, Uijeongbu St. Mary's Hospital and St. Vincent's Hospital. Gemcitabine was administered on days 1 and 8, and cisplatin or carboplatin was administered on day 1. Treatments were repeated every 3 weeks for a maximum of 4 cycles.

RESULTS:

The median age of the 62 patients was 73.5 years (range, 70 to 84 years). Forty-one (66%) patients exhibited comorbidity. The mean number of treatment cycles was 3.9. The compared average relative dose intensity of gemcitabine plus platinum chemotherapy was 84.8%. The median progression-free survival and overall survival (OS) were 5.0 months and 9.4 months, respectively. Reduced Eastern Cooperative Oncology Group (ECOG) performance status (none vs. > or =1) and weight loss ( or =5%) after treatment were found to have a significant effect on OS (p=0.01).

CONCLUSION:

Gemcitabine plus platinum chemotherapy is an effective treatment option with an acceptable level of toxicity in patients aged 70 years or older with good performance status in advanced NSCLC.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Platino (Metal) / Pérdida de Peso / Comorbilidad / Estudios Retrospectivos / Carboplatino / Cisplatino / Carcinoma de Pulmón de Células no Pequeñas / Supervivencia sin Enfermedad / Desoxicitidina / Quimioterapia Combinada Tipo de estudio: Estudio observacional Límite: Anciano / Humanos Idioma: Inglés Revista: Cancer Research and Treatment Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Platino (Metal) / Pérdida de Peso / Comorbilidad / Estudios Retrospectivos / Carboplatino / Cisplatino / Carcinoma de Pulmón de Células no Pequeñas / Supervivencia sin Enfermedad / Desoxicitidina / Quimioterapia Combinada Tipo de estudio: Estudio observacional Límite: Anciano / Humanos Idioma: Inglés Revista: Cancer Research and Treatment Año: 2011 Tipo del documento: Artículo