Effect of carbon disulfide exposure at different phases on the embryonic development in mid-pregnancy of female mice / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 139-141, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-346558
ABSTRACT
<p><b>OBJECTIVE</b>To explore the sensitive point of embryotoxicity of carbon disulphide on female mice.</p><p><b>METHODS</b>At the phases of follicle developing, implanting and post-implantation of blastocyst, female mice were injected intraperitoneally with carbon disulphide 631.4 mg/kg per day for three days while controls with plant oil. All indexes were detected at the fourteenth day of pregnancy.</p><p><b>RESULTS</b>(1) In follicle developing CS(2) exposed group, the weight of embryos fossa [(1.23 +/- 0.36) g was 41% less than that in controls [(2.08 +/- 0.48) g, P = 0.000], and in implanting CS(2) exposed group the weight of embryo fossa, and embryos [(1.27 +/- 0.97) g, and (0.12 +/- 0.09) g respectively] were 39% and 37% less than those in controls [(2.08 +/- 0.48), (0.19 +/- 0.06) g, P = 0.068, P = 0.045]; (2) In both follicle developing and implanting CS(2) exposed group, the weights of uterus and placenta were also less than those in controls (P < 0.01). (3) In post-implantation CS(2) exposed group, the above parameters were not significantly different from those in controls.</p><p><b>CONCLUSION</b>Follicle developing phase as well as implanting of blastocyst may be sensitive point for embryotoxicity induced by carbon disulphide.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Implantación del Embrión
/
Teratógenos
/
Disulfuro de Carbono
/
Desarrollo Embrionario
/
Toxicidad
/
Ratones Endogámicos
Límite:
Animales
/
Embarazo
Idioma:
Chino
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Año:
2005
Tipo del documento:
Artículo
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