The relationship between tumor necrosis factor A-308 gene polymorphism and susceptibility of severe periodontitis in adults / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the relationship between tumor necrosis factor A-308 gene polymorphism and susceptibility of severe periodontitis in adults.</p><p><b>METHODS</b>Buccal swabs from 65 adult patients with severe periodontitis and 96 periodontal healthy adult controls were obtained. DNA was extracted from each sample using Chelex-100 method, then PCR-RFLP was performed to determine the TNFA-308 genotype. Data were analyzed by statistics software.</p><p><b>RESULTS</b>A significant difference of genotype distribution was found between the patients and controls. The percentage of 1/1 type of the patients was much higher (P < 0.001). Risk Analysis showed odds ratio for allele 1 was 4.64.</p><p><b>CONCLUSION</b>This study suggested that TNFA-308 allele 1 maybe a marker of susceptibility to severe periodontitis.</p>