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Relation between single nucleotide polymorphism in estrogen-metabolizing genes COMT, CYP17 and breast cancer risk among Chinese women / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 453-456, 2003.
Artículo en Chino | WPRIM | ID: wpr-347404
ABSTRACT
<p><b>OBJECTIVE</b>To test the hypothesis whether polymorphism in estrogen-metabolizing genes, COMT and CYP17, impacts on the risk of breast cancer among Chinese women.</p><p><b>METHODS</b>COMT (Val158Met) and CYP17 (T1931C) polymorphisms were detected by PCR-based restriction fragment length polymorphism analysis in 250 breast cancer patients and 250 frequency-matched normal controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional logistic regression.</p><p><b>RESULTS</b>COMT Met/Met genotype was found in 10.4% of breast cancer patients, which was significantly higher (P = 0.03) than that in controls (5.2%). Women with Met/Met genotype showed 2-fold increased risk for breast cancer (adjusted OR 2.1, 95% CI 1.1 - 4.5) compared with those with Val/Val or Val/Met genotypes. Stratified analysis showed that the elevated risk of breast cancer, associating with the COMT Met/Met genotype, was evident only among premenopausal women (adjusted OR 4.1, 95% CI 1.2 - 17.3) but not among postmenopausal women (adjusted OR 1.3, 95% CI 0.5 - 3.5). There was no significant difference in the distribution of CYP17 genotypes between breast cancer patients and the control subjects (P = 0.83).</p><p><b>CONCLUSION</b>The allele encoding for low activity COMT, but not CYP17, may be a genetic risk factor for breast cancer among Chinese women.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias de la Mama / Menopausia / Catecol O-Metiltransferasa / Factores de Riesgo / Polimorfismo de Nucleótido Simple / Genética Tipo de estudio: Estudio de etiología / Factores de riesgo Límite: Adulto / Anciano / Femenino / Humanos Idioma: Chino Revista: Chinese Journal of Oncology Año: 2003 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias de la Mama / Menopausia / Catecol O-Metiltransferasa / Factores de Riesgo / Polimorfismo de Nucleótido Simple / Genética Tipo de estudio: Estudio de etiología / Factores de riesgo Límite: Adulto / Anciano / Femenino / Humanos Idioma: Chino Revista: Chinese Journal of Oncology Año: 2003 Tipo del documento: Artículo