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Mismatch pair defective phenotype in hereditary nonpolyposis colorectal cancer in the Chinese / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 420-424, 2003.
Artículo en Chino | WPRIM | ID: wpr-347412
ABSTRACT
<p><b>OBJECTIVE</b>To study the protein expression pattern of DNA mismatch repair genes hMSH(2), hMLH(1) and the microsatellite instability (MSI) status in the tumor tissue from hereditary nonpolyposis colorectal cancer in the Chinese.</p><p><b>METHODS</b>Fifty-eight families fulfilling different clinical criteria including Amsterdam Criteria (AC) (22/24 families, 38 tumors), Japanese Criteria (JC) (12/15 families, 16 tumors) and Bethesda Guidelines (BG) (12/19 patients, 13 tumors) were studied. Monoclonal antibodies against hMSH(2), hMLH(1) proteins and a panel of microsatellite markers (5 loci) including BAT26, BAT25, D2S123, D5S346 and D17S250 were used for study.</p><p><b>RESULTS</b>MSI-H was identified in all 22 (100%) AC tumors, with 81.8% (18/22) showing altered hMSH(2) or hMLH(1) expression; in 14/15 (93.8%) JC cancer, 1/1 (100%) JC adenoma, with 45.5% (5/11) showing altered hMSH(2) or hMLH(1) expression; and in 7/13 (53.8%) BG tumors, with 4/7 showing loss of hMSH(2) or hMLH(1) gene expression.</p><p><b>CONCLUSION</b>The frequency of MSI-H and loss of mismatch repair protein are different in the families fulfilling different clinical criteria. Amsterdam Criteria and Japanese Criteria are the two most useful criterion systems for identifying mismatched repair defective tumors. However, Bethesda Guidelines should also be used for detecting more such tumors. The combination of immunohistochemical methods and microsatellite instability analysis is an effective strategy to detect the mismatch repair defective tumors. A close correlation does exist between hMSH(2), hMLH(1) protein expression pattern and MSI status.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Inmunohistoquímica / Proteínas Nucleares / Proteínas Portadoras / Neoplasias Colorrectales Hereditarias sin Poliposis / Proteínas Proto-Oncogénicas / Repeticiones de Microsatélite / Disparidad de Par Base / Proteínas Adaptadoras Transductoras de Señales / Proteínas de Unión al ADN / Reparación del ADN Tipo de estudio: Guía de Práctica Clínica / Estudio pronóstico Límite: Humanos Idioma: Chino Revista: Chinese Journal of Oncology Año: 2003 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Inmunohistoquímica / Proteínas Nucleares / Proteínas Portadoras / Neoplasias Colorrectales Hereditarias sin Poliposis / Proteínas Proto-Oncogénicas / Repeticiones de Microsatélite / Disparidad de Par Base / Proteínas Adaptadoras Transductoras de Señales / Proteínas de Unión al ADN / Reparación del ADN Tipo de estudio: Guía de Práctica Clínica / Estudio pronóstico Límite: Humanos Idioma: Chino Revista: Chinese Journal of Oncology Año: 2003 Tipo del documento: Artículo