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A dynamic study on titer of EB virus VCA/IgA and EA/IgA in nasopharygeal carcinoma patients / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 243-245, 2003.
Artículo en Chino | WPRIM | ID: wpr-347452
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the change of EB virus VCA/IgA and EA/IgA titer during the development of nasopharyngeal carcinoma (NPC), and the role in screening for NPC.</p><p><b>METHODS</b>VCA/IgA and EA/IgA were monitored in a period of 12 years by immunoenzymatic titration from the sera of 54 NPC patients after primary serological screening.</p><p><b>RESULTS</b>VCA/IgA and EA/IgA titer had shown gradual increment 1 - 7 years before NPC was pathologically diagnosed. The mean titer of VCA/IgA was 121.04, 7 - 4 years before diagnosis. VCA/IgA titer ascended quickly within 3 years before diagnosis. The geometric mean titer (GMT) of VCA/IgA and EA/IgA were 176.86 and 16.49 when NPC was diagnosed, which descended quickly after radiotherapy and, in 4 years, approached the average titer of VCA/IgA positive population.</p><p><b>CONCLUSION</b>VCA/IgA titer rises uninterruptedly 3 years before NPC is diagnosed pathologically in most patients but their EA/IgA titer rises slowly. The detection of VCA/IgA titer can be used to find early NPC, whereas EA/IgA can not. The pre-clinical phase of NPC is 3 years according to this dynamic study.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Virología / Sangre / Inmunoglobulina A / Neoplasias Nasofaríngeas / Proteínas de la Cápside / Diagnóstico / Alergia e Inmunología / Detección Precoz del Cáncer / Anticuerpos Antivirales / Antígenos Virales Tipo de estudio: Estudio diagnóstico / Estudio de tamizaje Límite: Adulto / Humanos Idioma: Chino Revista: Chinese Journal of Oncology Año: 2003 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Virología / Sangre / Inmunoglobulina A / Neoplasias Nasofaríngeas / Proteínas de la Cápside / Diagnóstico / Alergia e Inmunología / Detección Precoz del Cáncer / Anticuerpos Antivirales / Antígenos Virales Tipo de estudio: Estudio diagnóstico / Estudio de tamizaje Límite: Adulto / Humanos Idioma: Chino Revista: Chinese Journal of Oncology Año: 2003 Tipo del documento: Artículo