A serial study of in cytogenetic change and morphology on the tetra-arsenic tetra-sulfide treatment in untreated or recurrent acute promyelocytic leukemia / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 163-167, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-347469
ABSTRACT
<p><b>OBJECTIVE</b>To study the morphologic and cytogenetic change in acute promyelocytic leukemia (APL) patients during the tetra-arsenic tetra-sulfide (TATS) treatment and the mechanism of TATS.</p><p><b>METHODS</b>The bone marrow cells of 13 newly diagnosed and 7 recurrent APL patients were studied through FISH and morphology during the TATS treatment by special and repeated marrow culture.</p><p><b>RESULTS</b>Cytomorphological study of 8 cases (6 untreated and 2 recurrent) showed that TATS could differentiate APL cells forward to mature granulocytes. There was obvious correlation between the reduced t (15; 17) positive cells and the reduced APL cells (r range 0.7298 - 0.9989). Except one patient with t (11; 17), 19 (13 untreated and 7 recurrent) with translocation t (15; 17) achieved clinical CR including 16 who achieved cytogenetic CR.</p><p><b>CONCLUSION</b>TATS has a differentiation-inducing effect on untreated and recurrent APL, with haematological CR and cytogenetic CR achieved. Measurement of t (15; 17) positive cells by FISH technique can reflect the change of APL cells objectively.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Arsenicales
/
Recurrencia
/
Sulfuros
/
Translocación Genética
/
Médula Ósea
/
Cromosomas Humanos Par 15
/
Cromosomas Humanos Par 17
/
Leucemia Promielocítica Aguda
/
Hibridación Fluorescente in Situ
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Oncology
Año:
2003
Tipo del documento:
Artículo
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