Protective effect of lytic cocktail (inhibition of stress) on lung injury in severe burn rat / 中华烧伤杂志
Chinese Journal of Burns
;
(6): 251-253, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-347608
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the protective effect of inhibition of stress (lytic cocktail) on lung injury in severe burn rats at early stage.</p><p><b>METHODS</b>Sprague-Dawley rats inflicted with 30% TBSA full-thickness burn were randomly divided into A group (n = 36, fluid resuscitation with administration of lytic cocktail), B group (n = 36, fluid resuscitation only). Lung function was evaluated by partial pressure of oxygen (PaO2) in arterial blood and histopathologic changes on 3, 5, 7, 10 post burn day (PBD). The levels of malonyldialdehyde (MDA), myeloperoxidase (MPO), tumor necrosis factor-alpha(TNF-alpha) and interferon-gamma (IFN-gamma) in lung tissue were measured at the same time points.</p><p><b>RESULTS</b>The PaO2 level in A group on 3 PBD (12.58 +/- 0.41 kPa) was significantly higher than that in B group (8.86 +/- 0.23 kPa, P < 0.01). Compared with those in B group, the levels of MDA and MPO were significantly decreased in A group at each time point (P < 0.05 or 0.01), the levels of TNF-alpha on 3, 5, 7 PBD (P < 0.05 or 0.01) and IFN-gamma on 5, 7, 14 PBD (P < 0.01) were also decreased in A group. Swollen lung mesenchyme was alleviated, infiltration of inflammatory cell was lessened in A group.</p><p><b>CONCLUSION</b>Lytic cocktail combined with immediate fluid resuscitation can inhibit stess response, downregulate the expression of inflammatory factor, ameliorate lung function in severe burn rat at early stage.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Terapéutica
/
Quemaduras
/
Distribución Aleatoria
/
Interferón gamma
/
Factor de Necrosis Tumoral alfa
/
Ratas Sprague-Dawley
/
Peroxidasa
/
Usos Terapéuticos
/
Lesión Pulmonar
/
Fluidoterapia
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Burns
Año:
2008
Tipo del documento:
Artículo
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