Nodal marginal zone B-cell lymphoma: a clinicopathologic study of 10 cases / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 529-533, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-347740
ABSTRACT
<p><b>OBJECTIVE</b>To study the morphologic features, immunophenotype, differential diagnosis and prognosis of nodal marginal zone B-cell lymphoma (NMZL).</p><p><b>METHODS</b>Light microscopic examination and immunohistochemical study were carried out in 10 cases of NMZL. Seven of which had follow-up information available.</p><p><b>RESULTS</b>All cases presented with good performance status at the time of diagnosis. Amongst the 7 cases with follow-up information available, most (6/7) were in advanced clinical stage (stage II to III). The one-year survival rate was 67%. A vaguely nodular growth pattern was observed in most cases of NMZL (5/10). The lymphoma was composed predominantly of atypical lymphoid cells resembling centrocytes (7/10). A predominance of monocytoid B-cell (2/10) or small lymphocytic (1/10) morphology was rare. Instead, the presence of a minor component of monocytoid B cells was not uncommon (5/10). Plasmacytoid or plasmacytic cells were also frequently found (8/10). The proliferation index ranged from 5% to 50%. Follicular dendritic cells appeared atrophic in 7 cases and variably hyperplasic in 3 cases.</p><p><b>CONCLUSIONS</b>Primary NMZL is rare. It has a unique growth pattern and most cases are composed predominantly of cells resembling centrocytes. Differential diagnosis includes lymphoplasmacytic lymphoma, lymph node involvement by extranodal marginal zone B-cell lymphoma and T-zone hyperplasia. The clinical stage is often high at presentation, with systemic dissemination. The prognosis of NMZL is thus relatively poor.</p>
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Inducción de Remisión
/
Tasa de Supervivencia
/
Estudios de Seguimiento
/
Macroglobulinemia de Waldenström
/
Linfoma de Células B de la Zona Marginal
/
Proteínas Proto-Oncogénicas c-bcl-2
/
Diagnóstico Diferencial
/
Quimioterapia
/
Ganglios Linfáticos
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio pronóstico
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Pathology
Año:
2007
Tipo del documento:
Artículo
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