Significant decrease of recent thymic output function in patients with severe benzene intoxication / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 114-117, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-347815
ABSTRACT
The aim of the present study was to investigate the level of T-cell receptor excision DNA circles (TREC) in peripheral blood mononuclear cells (PBMNC) of patients with severe benzene poison, thereby to evaluate the content of naive T cells and the recent thymic output function. Quantitative detection of TREC in DNA of PBMNCs from 16 normal individuals and 8 cases with severe benzene poison was preformed by real-time PCR using TaqMan technique. The results showed that TREC level was 6.69 +/- 4.79/1 000 PBMNCs in normal individuals, however, significant decrease was shown in patients with severe benzene poison (1.03 +/- 0.44/1 000 PBMNCs, P < 0.01). The TREC level was persistently low in period of benzene poisoning, even if peripheral blood cell counts were at normal levels. In conclusion, the recent thymic output function is remarkably decreased in patients with severe benzene intoxication, that may obviously damage the T cell immune function.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Intoxicación
/
Timo
/
Benceno
/
Sangre
/
ADN Circular
/
Leucocitos Mononucleares
/
Receptores de Antígenos de Linfocitos T
/
Reacción en Cadena de la Polimerasa
/
Alergia e Inmunología
/
Genética
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2005
Tipo del documento:
Artículo
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