Osteoblasts derived from mesenchymal stem cells harbor immunoregulatory effect / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 50-53, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-347828
ABSTRACT
In an attempt to study the immunoregulatory effect of osteoblasts derived from mesenchymal stem cells (MSC), MSC was induced to differentiate into osteoblasts for one week. The growth pattern and the phenotype were evaluated by MTT and flow cytometry respectively. The immunoregulatory effect was tested by the inhibitory effect on T cell proliferation. The result showed that during the differentiation cells grew fast and there was no significant change in the phenotypes but keeping CD73, CD105, CD44, CD29 positive and CD34, CD45, HLA-DR, CD86 negative. Osteocyte derived from MSC also showed immunosuppressive effect on T cell proliferation in adose-dependent manner. It is concluded that osteoblasts derived from MSC also harbored immunoregulatory effect.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteoblastos
/
Células de la Médula Ósea
/
Linfocitos T
/
Diferenciación Celular
/
Células Cultivadas
/
Linaje de la Célula
/
Biología Celular
/
Proliferación Celular
/
Alergia e Inmunología
/
Células Madre Mesenquimatosas
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2005
Tipo del documento:
Artículo
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